There are 56 FBS matchups on the Week 5 slate, with Wisconsin vs. USC among the best bets in terms of the over/under, according to our projections. For more suggestions, including parlay possibilities, see below.

Get insights and computer predictions for that matchup and more in the article below.

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College Football Computer Picks – Best Spread Bets

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Pick: Alabama +3.5 vs. Georgia

• Matchup: Georgia Bulldogs at Alabama Crimson Tide
• Projected Winner & Margin: Alabama by 6.1 points
• Time: 7:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Duke +2.5 vs. North Carolina

• Matchup: North Carolina Tar Heels at Duke Blue Devils
• Projected Winner & Margin: Duke by 5.3 points
• Time: 4:00 PM ET
• Date: Sept. 28
• TV Channel: ESPN2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Oklahoma -2.5 vs. Auburn

• Matchup: Oklahoma Sooners at Auburn Tigers
• Projected Winner & Margin: Oklahoma by 6.8 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Louisville +9.5 vs. Notre Dame

• Matchup: Louisville Cardinals at Notre Dame Fighting Irish
• Projected Winner & Margin: Notre Dame by 5.6 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: Peacock

Pick: USC -4.5 vs. Wisconsin

• Matchup: Wisconsin Badgers at USC Trojans
• Projected Winner & Margin: USC by 7.7 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

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College Football Computer Picks – Best Total Bets

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