NFL Week 16 Computer Predictions, Best Bets, Over/Under Picks

Published 10:17 pm Tuesday, December 17, 2024

Based on our projections, the best bet against the spread in the NFL among Week 16’s 16 matchups is Lions -6.5 — for more tips, including parlay opportunities, scroll down.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 16 Spread Bets

Jump to Matchup:

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JAX-LV | SF-MIA | DEN-LAC | HOU-KC | MIN-SEA

Pick: Raiders -1 vs. Jaguars

  • Matchup: Jacksonville Jaguars at Las Vegas Raiders
  • Projected Winner & Margin: Raiders by 1.1 points (Bet on this game at BetMGM)
  • Spread: Raiders -1
  • Time: 4:25 p.m. ET
  • Date: Dec. 22
  • TV Channel: CBS
  • Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers +1 vs. Dolphins

  • Matchup: San Francisco 49ers at Miami Dolphins
  • Projected Winner & Margin: 49ers by 1.5 points (Bet on this game at BetMGM)
  • Spread: Dolphins -1
  • Time: 4:25 p.m. ET
  • Date: Dec. 22
  • TV Channel: CBS
  • Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +2.5 vs. Chargers

  • Matchup: Denver Broncos at Los Angeles Chargers
  • Projected Winner & Margin: Broncos by 0.7 points (Bet on this game at BetMGM)
  • Spread: Chargers -2.5
  • Time: 8:15 p.m. ET
  • Date: Dec. 19
  • TV Channel: Amazon Prime Video
  • Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Chiefs -3 vs. Texans

  • Matchup: Houston Texans at Kansas City Chiefs
  • Projected Winner & Margin: Chiefs by 7.2 points (Bet on this game at BetMGM)
  • Spread: Chiefs -3
  • Time: 1 p.m. ET
  • Date: Dec. 21
  • TV Channel: NBC
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings -3 vs. Seahawks

  • Matchup: Minnesota Vikings at Seattle Seahawks
  • Projected Winner & Margin: Vikings by 4.6 points (Bet on this game at BetMGM)
  • Spread: Vikings -3
  • Time: 4:05 p.m. ET
  • Date: Dec. 22
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 16 Total Bets

Jump to Matchup:

Over 45.5 – Eagles vs. Commanders

Over 42.5 – Vikings vs. Seahawks

Over 45 – Steelers vs. Ravens

Over 41.5 – Texans vs. Chiefs

Under 48 – Lions vs. Bears

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