Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22

Published 6:22 pm Friday, February 21, 2025

There is no shortage of excitement on Saturday in college basketball play, including the Cal Baptist Lancers squaring off against the Grand Canyon Antelopes — that’s one of the 10 games our computer model recommends in terms of picks against the spread.

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Today’s NCAA Men’s Basketball Picks ATS

ATS Pick: Cal Baptist +9.5 vs. Grand Canyon

  • Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
  • Time: 8 p.m. ET
  • Date: February 22
  • Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
  • Spread: Grand Canyon (-9.5)
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

ATS Pick: Ole Miss +1.5 vs. Vanderbilt

  • Matchup: Ole Miss Rebels at Vanderbilt Commodores
  • Time: 3:30 p.m. ET
  • Date: February 22
  • Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
  • Spread: Vanderbilt (-1.5)
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: TCU +7.5 vs. Cincinnati

  • Matchup: TCU Horned Frogs at Cincinnati Bearcats
  • Time: 12 p.m. ET
  • Date: February 22
  • Computer Projection: Cincinnati by 3.9 points (Bet now on BetMGM)
  • Spread: Cincinnati (-7.5)
  • TV Channel: ESPN2
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Kentucky +9.5 vs. Alabama

  • Matchup: Kentucky Wildcats at Alabama Crimson Tide
  • Time: 6 p.m. ET
  • Date: February 22
  • Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
  • Spread: Alabama (-9.5)
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: West Virginia +11.5 vs. Texas Tech

  • Matchup: West Virginia Mountaineers at Texas Tech Red Raiders
  • Time: 1 p.m. ET
  • Date: February 22
  • Computer Projection: Texas Tech by 8.1 points (Bet now on BetMGM)
  • Spread: Texas Tech (-11.5)
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

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ATS Pick: McNeese -10.5 vs. Texas A&M-CC

  • Matchup: Texas A&M-CC Islanders at McNeese Cowboys
  • Time: 5 p.m. ET
  • Date: February 22
  • Computer Projection: McNeese by 13.9 points (Bet now on BetMGM)
  • Spread: McNeese (-10.5)
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

ATS Pick: UNC Greensboro -2.5 vs. Mercer

  • Matchup: UNC Greensboro Spartans at Mercer Bears
  • Time: 2 p.m. ET
  • Date: February 22
  • Computer Projection: UNC Greensboro by 5.2 points (Bet now on BetMGM)
  • Spread: UNC Greensboro (-2.5)
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

ATS Pick: Georgia +18.5 vs. Auburn

  • Matchup: Georgia Bulldogs at Auburn Tigers
  • Time: 4 p.m. ET
  • Date: February 22
  • Computer Projection: Auburn by 15.9 points (Bet now on BetMGM)
  • Spread: Auburn (-18.5)
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: BYU +7.5 vs. Arizona

  • Matchup: BYU Cougars at Arizona Wildcats
  • Time: 10 p.m. ET
  • Date: February 22
  • Computer Projection: Arizona by 4.9 points (Bet now on BetMGM)
  • Spread: Arizona (-7.5)
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: SMU +1.5 vs. Clemson

  • Matchup: Clemson Tigers at SMU Mustangs
  • Time: 4 p.m. ET
  • Date: February 22
  • Computer Projection: SMU by 1 points (Bet now on BetMGM)
  • Spread: Clemson (-1.5)
  • TV Channel: ACC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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